Being that I'm still on assignment, I've decided to let you in on the experiment that I did on myself to try to understand the nature of Ketosis Prone Type 2 diabetes or as I call it Abrupt onset type 2 diabetes.
Okay, a bit of a review. Ketosis prone type 2 diabetes is an abrupt onset type 2 diabetes though highly prevalent in people of color it can and does pop up in any group. The fact is that KPDM is actually a subset of this form of diabetes. I know LADA's that have gone DKA. There is a real question in my mind whether Abrupt onset T2 (AOT2) is a type of diabetes or simply a mechanism through which diabetes is expressed.
At any rate, this is a diabetes that comes on very strong because the body simply quits producing insulin. It is therefore classified as a type 1 diabetes, T1b. It comes out of nowhere. In 6 months time a person can go from near normal blood sugars to DKA. I talk about this process in these posts. Relapse
It has also been shown to vanish just as quickly, if handled correctly. In the space of a year, a person can go from near normal blood sugars to close to death from DKA and then back again. This not a regular diabetes and so far has failed serious classification. It is so fantastical that most people don't know it exists, even those most susceptible to it such as people of Latin, African and Asian descent.
I, however, got lucky. About six months ago, I found myself with a revived 1st phase insulin response. I wasn't content with this. I had to find out what happened and how this could be and I kept experimenting until I not only found it but was able to manipulate it. I could turn it off and on with a simple manipulation. You can read about this process through this link, This is a dialogue on diabetesforums where I talk about this experiment
Here are some of the citations that I dug up to back up what I believed to be the cause of my suddenly restored 1st phase insulin response.
Non-steroidal anti-inflammatory drugs increase insulin release from beta-cells by inhibiting atp-sensitive potassium channel
EFFECT OF NAPROXEN ON GLUCOSE METABOLISM AND TOLBUTAMIDE KINETICS AND DYNAMICS IN MATURITY ONSET DIABETICS
Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice
Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes
Targeting INflammation using SALsalate for Type 2 Diabetes.
Potential Role of Salicylates in Type 2 Diabetes
This got me to thinking about KPDM and its quick rise and fall which you can read here. Here
Now you know. It was a NSAID called Sodium Naproxen taken as needed. The net cost was about 60 cents. More when I have the time.
Posts
I was in the salsalate study at Joslin, and the drug (very high dose) did indeed restore my phase 1 response. They're doing more studies of this drug. I don't know if they're still recruiting.
ReplyDeleteHi Gretchen
ReplyDeleteYour comment is interesting because I thought that this sort of thing might work on you because, as I remember, your T2 was abrupt. My thinking being that Abrupt Onset is a sign of malfunctioning of a higher order system. I picked the hypothalamus as this system.
Did you write about your experience? I would love to read about it.
Mike