The accepted knowledge is that Diabetes destroys gradually over years. Ketosis Prone Type 2 diabetes is an acute form of type 2. This type 2 can reach fasting blood sugars of 300 or higher in months. This blog brings together all the documentation that I could find in the world and my speculation of what it means for KPD’s in specific and diabetics in general. I ask you to leave your stories about what happened to you so that we can all gain a better understanding of what we are dealing with.

Thursday, March 18, 2010

Grocery Shopping or starvation amongst plenty

Before diabetes, I could hang out in a grocery store for hours because I love to eat. Now, I'm in and out in about thirty minutes and that's a weeks worth up shopping. I use to wander the aisles savoring the possibilities with all the possible combinations. There was just so so much and decisions that excluded one thing or another almost seemed punitive.
I've obviously had a change of heart. Now I roll in the store and for the most part all I see are piles of sugar. I grab my green veggies and never even look at the fruits - sugar. The bread section is next and I wouldn't even bother to go through here if the deli wasn't on the other side instead I cruise through healthy breads - sugar, multiwheat breads - sugar, organic, fresh baked bread - sugar, flatbread - sugar, unleavened bread - sugar, spelt wheat bread - sugar. It's packaged in different ways, with different claims on them with various shapes but all I'm seeing are piles of white sugar sitting there.
They didn't always look this way but I've got a meter now and it colors my world. Once the meter has marked a food "sugar", it turns white and granular and I back away from it like its a nasty beast temporarily slumbering. I slink passed the now deadly pasta, rice, and noodles and give a fond but fleeting glance at the couscous as it sits seductively in its box.
Okay, that's bad but at least, it's expected. What really kills me is that I can't even buy dressing without finding sugar in it. The truth is about the only thing they don't add sugar to, that I know for sure, is toilet paper. If you know different please keep it to yourself. Life is hard enough as it is

Wednesday, March 10, 2010

G6PD - something else you haven't heard of

What is G6PD and why should a KPD care? Well, it's another one of your problems and it may be the reason  why KPD's should be wary of carbohydrates.

G6PD is an enzyme that helps in the breakdown of carbohydrates. If it isn't present then certain pathways that deal with glucose metabolism aren't activated. There's a lot more to it but the short form is that glucose is a bad actor and this helps keep it contained. You more than likely are deficient here. This shouldn't be a great surprise since this is the most common deficiency in humans.

G6PD deficiency: its role in the high prevalence of hypertension and diabetes mellitus

Currently, there are 200 million people worldwide with red cell x-linked chromosome defects who, with the persistent ingestion of refined carbohydrates, are at greater risk of developing hypertension or diabetes mellitus... 

What has been found is that KPD's are far more likely to have G6PD deficiency than other diabetics. You could view it as a marker for KPD.

High Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency without Gene Mutation Suggests a Novel Genetic Mechanism Predisposing to Ketosis-Prone Diabetes 

The prevalence of G6PD deficiency was higher in KPD than in T2DM and controls (42.3%; 16.9%; 16.4%; P = 0.01). In KPD, but not in T2DM, insulin deficiency was proportional to the decreased G6PD activity (r = 0.33; P = 0.04).

42% to 17% that's big. What I find interesting is that insulin deficiency was proportionate to decreased G6PD activity. The other really important part is that, for the most part, there was NO gene mutations beyond regular type 2's controls. So we are looking at a difference of about 20% that comes from some where but it isn't genetic.This, however, was done on a West African population so it could be a bit skewed.

If you took the time to read this post, you really should read this other post which puts it all in context for this type of diabetes. Here

Saturday, March 6, 2010

Being type 1 then type 2 only part of the story or deadly, common and dangerous

There are 4 classifications of KPD's. We are classified by antibodies and beta cell functioning (c-peptide).
The majority of us are Antibody negative and Beta cell positive (c-pep >.9) ..... A-B+
The others are: Antibody positive and Beta cell positive ......A+B+
Antibody positive and Beta cell negative ......A+B-
Antibody negative and Beta cell negative ......A-B-

You can see how wild this gets LADA's would be part of the A+ groups and a type 1's would be part of the B- groups. Type 2's are the B+ groups. You can understand why someone with poor to no insulin secretion might go DKA but how do you explain DKA with normal insulin secretion?

The really ugly part is that this tends to be newly diagnosed and sadly the DKA can return quickly.

Yep, deadly and common and most of you who have it, have no idea of your danger.